MISHA

Program 02 · The data infrastructure

Patient Registry

Family-controlled, IRB-approved records and natural-history data, federated so many small cohorts become one research surface.

What it does

  • 01

    Collect the natural-history data a trial actually needs: longitudinal audiograms, imaging, and hearing trajectory over time.

  • 02

    Keep records family-controlled and IRB-approved. Families own their data and consent per use. We will never sell it, because it is not ours to sell.

  • 03

    Federate on the RARE-X model so a small STRC cohort sits inside a much larger shared research surface, extensible to adjacent hearing-genetics conditions.

Why it matters

A single rare-disease registry is too small to power a study. Federated, many become large enough to matter. Natural-history data is what regulators now accept as an external control arm, which is how tiny populations run rigorous trials. RARE-X, now part of Global Genes, already runs this federated model across dozens of rare-disease communities.

Sources (2)

Where it stands

Planning. Year-one targets are a RARE-X agreement, the first families enrolled, and independent IRB approval. Patient data never lives in the public vault. Aggregates only.